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LUTALYSE® HighCon Injection

(dinoprost tromethamine injection)

LUTALYSE® HighCon Injection (dinoprost tromethamine injection) is a high-concentration formula of LUTALYSE® Injection (dinoprost tromethamine injection), the most veterinarian prescribed and producer used prostaglandin in the market.1 LUTALYSE HighCon allows for a 2-mL dose for convenience and flexibility in artificial insemination synchronization programs.

LUTALYSE HighCon is approved for use with FACTREL® Injection (gonadorelin injection) to synchronize estrous cycles to allow for fixed-time artificial insemination (FTAI) in lactating dairy cows. It also is approved for use with Eazi-Breed CIDR® Cattle Inserts in heifers and cows to improve breeding efficiency and pregnancy success. It’s important to note that LUTALYSE HighCon188体育平台 is approved for use in cattle only, not equine or swine like LUTALYSE.  

At Zoetis, we understand the changing needs of today’s cattle producers and veterinarians. We are committed to developing solutions, including multiple estrous synchronization options. Our focus is on you and your desired outcomes that reflect your measures of success. Improving reproduction is a team effort.

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  • LUTALYSE HighCon is:

    • Approved for a convenient 2-mL dose
    • The first-to-market prostaglandin with an FDA-approved subcutaneous claim in addition to intramuscular administration
      • Now producers and veterinarians have flexible options for route of administration consistent with strict Beef Quality Assurance (BQA) standards and Dairy Animal Care and Quality Assurance (DACQA).
    • Available in three bottle sizes, allowing choices that best fit management needs for handling and administration
      • 20-mL vial contains 10 doses
      • 100-mL vial contains 50 doses
      • 250-mL vial contains 125 doses
    • An entirely natural prostaglandin
    • Free from a requirement of meat or milk withdrawal
    • Useful therapeutically for controlled breeding

    A synchronized breeding program with LUTALYSE HighCon and FACTREL can:

    • Improve pregnancy rates
    • Reduce time necessary for heat detection
    • Make more efficient use of labor
    • Reduce cull rates


  • Effective in animals having a functional corpus luteum in the following applications:

    • For use with FACTREL for estrous synchronization to allow for FTAI with the following framework:


    Example 1

    Example 2

    Example 3

    188体育平台Day 0 (Monday)

    1st FACTREL

    1st FACTREL

    1st FACTREL

    Day 7 (the following Monday)

    LUTALYSE HighCon

    LUTALYSE HighCon

    LUTALYSE® HighCon

    Day 9 (Wednesday)

    2nd FACTREL + FTAI at 48 hours after LUTALYSE HighCon

    2nd FACTREL 48 hours after LUTALYSE HighCon

    2nd FACTREL 56 hours after LUTALYSE HighCon

    Day 10 (Thursday)


    FTAI 24 hours after 2nd FACTREL

    FTAI 16 hours after FACTREL®

    • For estrous synchronization, inject 2 mL LUTALYSE HighCon subcutaneously (subQ) or intramuscularly (IM) either once or twice at 10- to 12-day intervals.
    • For treatment of unobserved estrus, inject a 2-mL dose subQ or IM. If estrus has not been observed by 80 hours after injection, breed at 80 hours; if the cow returns to estrus, breed at the usual time relative to estrus.
    • For postpartum treatment of pyometra, inject a dose of 2 mL subQ or IM at signs of pyometra (presence of a corpus luteum on the ovary and uterine horns containing fluid but not a conceptus based on palpation).
    • LUTALYSE HighCon is approved for use in cattle only, not equine or swine like LUTALYSE.


IMPORTANT SAFETY INFORMATION FOR LUTALYSE/LUTALYSE HIGHCON: Women of childbearing age and persons with respiratory problems should exercise extreme caution when handling LUTALYSE/LUTALYSE HighCon. LUTALYSE/LUTALYSE HighCon is readily absorbed through the skin and may cause abortion and/or bronchiospasms, therefore spillage on the skin should be washed off immediately with soap and water. Aseptic technique should be used to reduce the possibility of post-injection clostridial infections. Do not administer LUTALYSE/LUTALYSE HighCon188体育平台 in pregnant cattle unless cessation of pregnancy is desired. See . See .


IMPORTANT SAFETY INFORMATION FOR EAZI-BREED CIDR: Avoid contact with skin by wearing protective gloves when handling EAZI-BREED CIDR inserts. Do not use in heifers of insufficient size or age for breeding or in cattle with abnormal, immature, or infected genital tracts. Do not use inserts more than once.



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This site is intended for U.S. Animal Healthcare Professionals. The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

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